5-HT2A Receptor

The 5-HT2A receptor is a subtype of the 5-HT₂ receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor.

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine)

A psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Sonoran Desert toad.

 

18-Methoxycoronaridine (18-MC)

A derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemists Upul K. Bandarage and Martin E. Kuehne from the University of Vermont.

Accelerated Approval

A set of regulations instituted in 1992 by the FDA. The process allows for expedited approval of drugs that treat serious conditions, “and that fill an unmet medical need based on a surrogate endpoint.

Acid Tests

A series of parties held by author Ken Kesey primarily in the San Francisco Bay Area during the mid-1960s, centered on the use of and advocacy for the psychedelic drug LSD, commonly known as "acid".

Active Placebo

An active placebo is a placebo that produces noticeable side effects that may convince the person being treated that they are receiving a legitimate treatment, rather than an ineffective placebo.

Afterglow

A state characterized by positive physical and mental effects that persists after the primary effects of a drug have subsided. Psychiatrist Walter Pahnke described afterglow as an “elevated and energetic mood with a relative freedom from concerns of the past and from guilt and anxiety.”

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response

Amanda Feilding

An English drug policy reformer, lobbyist, and research coordinator. In 1998, she founded the Foundation to Further Consciousness, later renamed to the Beckley Foundation.

Anxiolytic

An anxiolytic is a medication or other intervention that reduces anxiety.

 

Ayahuasca

A psychoactive brew used both socially and as ceremonial spiritual medicine among the indigenous peoples of the Amazon basin. It is a psychedelic and entheogenic brew commonly made out of the Banisteriopsis caapi vine, the Psychotria viridis shrub or a substitute, and possibly other ingredients.

Barbiturate

A drug that acts as a central nervous system depressant. Barbiturates are effective as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects.

The Beckley Foundation

A UK-based think tank and UN-accredited NGO, dedicated to activating global drug policy reform and initiating scientific research into psychoactive substances. It was founded in 1998, and is directed by Amanda Feilding, Countess of Wemyss.

Breakthrough Therapy Designation

A United States Food and Drug Administration designation that expedites drug development that was created by Congress under Section 902 of the 9 July 2012 Food and Drug Administration Safety and Innovation Act.

 

Bunk Police

A private company that sells reagent test kits.

Carl Hart

An American psychologist and neuroscientist. He is a professor of psychology at Columbia University. Hart is known for his research in drug abuse and drug addiction.

 

Center for Drug Evaluation and Research (CDER)

 A division of the U.S. Food and Drug Administration (FDA) that monitors most drugs as defined in the Food, Drug, and Cosmetic Act.

 

Centre for Psychedelic Research, Imperial College London

Led by Dr Robin Carhart-Harris, the Centre focuses on two main research themes: the use of psychedelics in mental health care; and as tools to probe the brain’s basis of consciousness.

 

Comedown

A phase of drug withdrawal that involves the deterioration in mood and energy that occurs when a psychoactive drug, clears from the blood in the bloodstream.

Cluster Headaches

A neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye.

Compass Pathways

A mental health care company dedicated to controlling patients in regards to psychedelics.

Controlled Drugs and Substances Dealer’s License (Canada)

This registration permits practitioners to distribute, dispense, conduct research, administer, or procure controlled substances in the course of their professional practice as permitted by the Department of Public Health or other governing agency.

Controlled Substances Act (CSA)

The statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

DanceSafe

A public health organization promoting health and safety within the nightlife and electronic music community. Founded in the San Francisco Bay Area in 1998 by Emanuel Sferios.

 

Default Mode Network (DMN)

A large-scale brain network primarily composed of the medial prefrontal cortex, posterior cingulate cortex/precuneus and angular gyrus. It is best known for being active when a person is not focused on the outside world and the brain is at wakeful rest, such as during daydreaming and mind-wandering.

Digital Therapeutics (DTx)

Evidence-based therapeutic interventions driven by high quality software programs to prevent, manage, or treat a medical disorder or disease.

Dissociative Anaesthetics

A class of substances which distort perception of sight and sound and produce feelings of detachment – dissociation – from the environment and/or self.

DoubleBlind Magazine

A biannual print magazine and media company covering timely, untold stories about the expansion of psychedelics around the globe.

DMT (N,N-Dimethyltryptamine)

A tryptamine drug that occurs naturally in many plants and animals. It is also referred to as the “spirit molecule” due to the intense psychedelic experience.

Dopamine

A neurotransmitter that plays several important roles in the brain and body. It is an organic chemical of the catecholamine and phenethylamine families. Dopamine constitutes about 80% of the catecholamine content in the brain.

Ego Death

 The term used to describe “a complete loss of subjective self-identity.”

Empathogens

A class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy.

Entheogen

A chemical substance, typically of plant origin, that is ingested to produce a nonordinary state of consciousness for religious or spiritual purposes.

Erowid

A non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs, plants, chemicals, and technologies.

Fast Track (FDA Designation)

A designation by the United States Food and Drug Administration (FDA) of an investigational drug for expedited review to facilitate development of drugs which treat a serious or life-threatening condition and fill an unmet medical need. Fast Track designation must be requested by the drug company.

 

Forced Swim Test (FST)

A rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states.

Free Base

The conjugate base form of an amine, as opposed to its conjugate acid form. The amine is often an alkaloid, such as nicotine, cocaine, morphine, and ephedrine, or derivatives thereof. Freebasing is a more efficient method of self-administering alkaloids via the smoking route.

Full Agonist

GHB

GMP/cGMP (Good Manufacturing Practices)

Hallucinogen

Harm Reduction

Harvard Psilocybin Project

Head-Twitch Response (HTR)

Holotropic Breathwork

Ibogaine

IM

IV

Indication

Investigational New Drug (IND)

Ketamine
Lucid News

LSD (lysergic acid diethylamide)

Magic Truffle

Major Depressive Disorder (MDD)

MAPS (Multidisciplinary Association for Psychedelic Studies)

MAOI

María Sabina

MDMA (3,4-methylenedioxymethamphetamine)

Mescaline

Meclizine

Microdosing

MK-Ultra

Mycelium

Mystical Experience Questionnaire

Naloxone

Narcotic

Neuroplasticity

Neurotoxic

New Drug Application (NDA)

Nightshade

NMDA Receptor (NMDAR)

Observational Study

Open Field Test (OFT)

Open Label

Oneirogen

Orange Sunshine

Orphan Drug Designation

Phase I (Clinical Trial)

Phase II (Clinical Trial)

Phase III (Clinical Trial)

Phase IV (Clinical Trial)

Phenethylamines

Placebo

Post-Traumatic Stress Disorder (PTSD)

Pre-Investigational New Drug (IND) Meeting

Psilocin (4-HO-DMT)

Psilocybin

Psychedelic-Assisted Therapy (PAT)

Psychoactive

Psychonaut

Psychotropic

R. Gordon Wasson

Randomized Control Trial (RCT)

Ram Dass aka Richard Alpert

Rick Doblin

Salvia

Sclerotia

Section 56 (Exemption)

Serotonin

Set and Setting

Shaman

Soma

Special Access Program (SAP)

Spore

SSRI (Selective Serotonin Reuptake Inhibitor)

Substrate

Summer of Love

Synesthesia

Tail Suspension Test (TST)

Timothy Leary

Treatment-Resistant Depression (TRD)

Trip

Trip Sitter

Tryptamines

Vasoconstriction

Zendo Project